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KMID : 0362919840020010001
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1984 Volume.2 No. 1 p.1 ~ p.9
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An Experimental Study on the Effect of Repeated Hyperthermia on the Radiation Injury
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Choi Young-Hi
Park Charn-Il
Han Man-Chung
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Abstract
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To evaluate the influence of prior heat treatment on the thermal enhancement of irradiation effect after hyperthermia, an experimental study was carried out using a total of 80 mice.
Hyperthermia was carried out at 43℃ for 40 minutes and was repeated with various intervals. A single dose of 3,000 rad was delivered on skin of mouse tail immediately after the second hyperthermia.
The skin changes of the irradiated mouse tail were observed from 7th to 35th post-irradiation days, and the skin scores were analyzed.
The results are as follows;
1. The radiation damage on mouse skin increased significantly when radiation was combined with hyperthermia.
2. The radiation damage after repeated hyperthermia is significantly less than that after single hyperthermia, when the interval is 1 to 6 days.
3. As a results, thermal tolerance persists from 1 through 6 days after the initial hyperthermia.
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